Pharmacological Inhibition of Endogenous Hydrogen Sulfide Production Slows Bladder Cancer Progression in an Intravesical Murine Model.

ABSTRACT: Present bladder cancer therapies have relatively limited therapeutic impact and account for one of the highest lifetime treatment costs per patient. Therefore, there is an urgent need to explore novel and optimized treatment strategies. The present study investigated the effects of inhibiting endogenous hydrogen sulfide (H₂S) production on bladder cell viability and in vivo tumor progression. We targeted the H₂S-producing enzyme, cystathionine γ-lyase, in 5637 cells using propargylglycine (H₂S inhibitor) and performed cytofluorimetric analysis to evaluate cell viability. We then tested the efficacy of propargylglycine alone or in combination with gemcitabine (conventional chemotherapy) in an intravesical murine model of bladder cancer. Magnetic resonance im

SUBMITTER: Relouw S 

PROVIDER: S-EPMC11435360 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature