Analysis of Lipophilicity and Pharmacokinetic Parameters of Dipyridothiazine Dimers with Anticancer Potency.

ABSTRACT: Lipophilicity is an essential parameter of a compound that determines the solubility and pharmacokinetic properties that determine the transport of the drug to the molecular target. Dimers of dipyridothiazines are diazaphenothiazine derivatives exhibiting diverse anticancer potential in vitro, which is related to their affinity for histone deacetylase. In this study, the lipophilicity of 16 isomeric dipyridothiazine dimers was investigated theoretically and experimentally by reversed-phase thin-layer chromatography (RP-TLC) in an acetone-TRIS buffer (pH = 7.4). The relative lipophilicity parameter R_M0 and specific hydrophobic surface area b were significantly intercorrelated, showing congeneric classes of dimers. The parameter R_M0 was transformed into parameter logP

SUBMITTER: Martula E 

PROVIDER: S-EPMC11435374 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature