Synthesis of Poly(L-lactide)-poly(ε-caprolactone)-poly(ethylene glycol) Terpolymer Grafted onto Partially Oxidized Carbon Nanotube Nanocomposites for Drug Delivery.

ABSTRACT: Nanocomposites prepared with a terpolymer of poly(L-lactide) (PLLA)-poly(ε-caprolactone) (PCL)-poly(ethylene glycol) (PEG) and partially oxidized carbon nanotubes (CNTs_po) were synthesized and characterized to evaluate their ability to act as an effective nanocarrier of the anticancer drug methotrexate. The homopolymers of PLLA and PCL were synthesized through ring-opening polymerization (ROP) and characterized through gel permeation chromatography (GPC). The PLLA-PCL-PEG terpolymers were synthesized through a four-step chemical route using oxalyl chloride as a linker agent and analyzed with ¹H-NMR, ¹³C-NMR, and FTIR spectroscopies. Additionally, the nanocomposites were characterized through FTIR, and X-ray photoelectron spectroscopy (XPS), as well as the d

SUBMITTER: Gonzalez-Iniguez KJ 

PROVIDER: S-EPMC11435386 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature