In Vitro Prediction of Skin-Sensitizing Potency Using the GARDskin Dose-Response Assay: A Simple Regression Approach.

ABSTRACT: Toxicological assessments of skin sensitizers have progressed towards a higher reliance on non-animal methods. Current technological trends aim to extend the utility of non-animal methods to accurately characterize skin-sensitizing potency. The GARDskin Dose-Response assay has previously been described; it was shown that its main readout, cDV₀ concentration, is associated with skin-sensitizing potency. The ability to predict potency from cDV₀ in the form of NESILs derived from LLNAs or human NOELs was evaluated. The assessment of a dataset of 30 chemicals showed that the cDV₀ values still correlated strongly and significantly with both LLNA EC3 and human NOEL values (ρ = 0.645-0.787 [p < 1 × 10^-3]). A composite potency value that combined

SUBMITTER: Gradin R 

PROVIDER: S-EPMC11435491 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature