Neutralizing Nanobodies against Venoms from <i>Naja haje</i> Species Captured in North Africa.

ABSTRACT: Snakebite envenoming (SBE) remains a severely neglected public health issue, particularly affecting tropical and subtropical regions, with Africa experiencing an estimated 435,000 to 580,000 snakebites annually, leading to high morbidity and mortality rates, especially across Africa and Asia. Recognized as a Neglected Tropical Disease, SBE management is further complicated by the inadequate efficacy of current antivenom treatments. Of particular concern are cobras (Naja sp.), whose neurotoxins can induce rapid fatal respiratory paralysis. In this study, we investigate the potential of nanobodies as a promising next-generation of immunotherapeutics against cobra venoms. Through a dual strategy of the characterization of venom toxic fractions from cobras captured for the first time in

SUBMITTER: Mejri H 

PROVIDER: S-EPMC11435604 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature