Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues.

ABSTRACT: A major advantage of the mouse model lies in the increasing information on its genome, transcriptome, and proteome, as well as in the availability of a fast growing number of targeted and induced mutant alleles. However, data from comparative transcriptome and proteome analyses in this model organism are very limited. We use DNA chip-based RNA expression profiling and 2D gel electrophoresis, combined with peptide mass fingerprinting of liver and kidney, to explore the feasibility of such comprehensive gene expression analyses. Although protein analyses mostly identify known metabolic enzymes and structural proteins, transcriptome analyses reveal the differential expression of functionally diverse and not yet described genes. The comparative analysis suggests correlation between transcripti

SUBMITTER: Mijalski T 

PROVIDER: S-EPMC1143582 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature