Thermoregulation Effects of <i>Phoneutria nigriventer</i> Isolated Toxins in Rats.

ABSTRACT: Body temperature is primarily regulated by the hypothalamus, ensuring proper metabolic function. Envenomation by Phoneutria nigriventer can cause symptoms such as hypothermia, hyperthermia, sweating, and shivering, all related to thermoregulation. This study aims to analyze and identify components of the venom that affect thermoregulation and to evaluate possible mechanisms. Rats were used for thermoregulation analysis, venom fractionation by gel filtration and reverse-phase chromatography (C18), and sequencing by Edman degradation. The venom exhibited hypothermic effects in rats, while its fractions demonstrated both hypothermic (pool II) and hyperthermic (pool III) effects. Further separations of the pools with C18 identified specific peaks responsible for these effects. However,

SUBMITTER: Butkeraitis CB 

PROVIDER: S-EPMC11435823 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature