Enzymatic Hydrolysis of Resorcylic Acid Lactones by an <i>Aeromicrobium</i> sp.

ABSTRACT: Zearalenone and radicicol are resorcylic acid lactones produced by numerous plant pathogenic fungi. Zearalenone is a non-steroidal estrogen mimic that can cause serious reproductive issues in livestock that consume contaminated feed. Radicicol is a potent inhibitor of the molecular chaperone Hsp90, which, in plants, has an important role in coordinating the host's immune response during infection. Here, we describe the identification and characterization of a soil-borne strain of the Gram-positive bacterium Aeromicrobium sp. capable of hydrolyzing the macrolide ring of resorcylic acid lactones, including zearalenone and radicicol. Proteomic analysis of biochemically enriched fractions from the isolated and cultured bacterium identified an α/β-hydrolase responsible for this activity.

SUBMITTER: Hoogstra SJ 

PROVIDER: S-EPMC11435890 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature