Combining RNA Interference and RIG-I Activation to Inhibit Hepatitis E Virus Replication.

ABSTRACT: Hepatitis E virus (HEV) poses a significant global health threat, with an estimated 20 million infections occurring annually. Despite being a self-limiting illness, in most cases, HEV infection can lead to severe outcomes, particularly in pregnant women and individuals with pre-existing liver disease. In the absence of specific antiviral treatments, the exploration of RNAi interference (RNAi) as a targeted strategy provides valuable insights for urgently needed therapeutic interventions against Hepatitis E. We designed small interfering RNAs (siRNAs) against HEV, which target the helicase domain and the open reading frame 3 (ORF3). These target regions will reduce the risk of viral escape through mutations, as they belong to the most conserved regions in the HEV genome. The siRNAs targetin

SUBMITTER: Ziersch M 

PROVIDER: S-EPMC11435946 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature