Toll-Like Receptor Genes and Risk of Latent Tuberculosis Infection in People Infected with HIV-1.

ABSTRACT: The purpose of this study was to determine the contribution of genetic factors, i.e., the level of expression and polymorphisms of Toll-like receptors (TLR), to the susceptibility of latent tuberculosis infection in a Russian cohort of individuals infected with HIV. The patients (n = 317) with confirmed HIV infection were divided into two groups according to the results of the STANDARD E TB-Feron test: 63 cases with a latent TB infection and 274 controls without LTBI. Total DNA and RNA were isolated from whole-blood samples. SNP genotyping and expression levels of five TLR genes (TLR1, TLR2, TLR4, TLR6, and TLR8) were determined by means of real-time PCR. There were no significant differences in the expression levels of the TLRs between the case and control groups. In addition, we d

SUBMITTER: Salamaikina S 

PROVIDER: S-EPMC11436194 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature