A High-Throughput Method for Quantifying Drosophila Fecundity.

ABSTRACT: The fruit fly, Drosophila melanogaster, is an experimentally tractable model system that has recently emerged as a powerful "new approach methodology" (NAM) for chemical safety testing. As oogenesis is well conserved at the molecular and cellular level, measurements of Drosophila fecundity can be useful for identifying chemicals that affect reproductive health across species. However, standard Drosophila fecundity assays have been difficult to perform in a high-throughput manner because experimental factors such as the physiological state of the flies and environmental cues must be carefully controlled to achieve consistent results. In addition, exposing flies to a large number of different experimental conditions (such as chemical additives in the diet) and manually c

SUBMITTER: Gomez A 

PROVIDER: S-EPMC11436201 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature