Comparative Genomic Analysis of Mycobacterium tuberculosis Isolates Circulating in North Santander, Colombia.

ABSTRACT: Tuberculosis (TB) is an important infectious disease in relation to global public health and is caused species of the Mycobacterium tuberculosis complex (MTBC). In this study, we used whole-genome sequencing (WGS) and comparative genomics to investigate the genetic diversity of M. tuberculosis (Mtb) isolates circulating in North Santander (NS), Colombia. WGS was used for the phylogenetic and lineage characterization of 18 isolates of Mtb typed with orphan genotypes from 11 municipalities of NS between 2015 and 2018. The isolates studied were included in six sublineages from L4; the most frequent were 4.1.2.1, 4.3.3, and 4.3.4.2, corresponding to a proportion of 22.2%. The genome analysis conducted allowed the identification of a set of genetic variants mainly as

SUBMITTER: Bohada-Lizarazo DP 

PROVIDER: S-EPMC11436241 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature