Acute nicotinamide riboside supplementation increases human cerebral NAD⁺ levels in vivo.

ABSTRACT:

Purpose

The purpose of this study was to determine the effect of acute nicotinamide riboside (NR) supplementation on cerebral nicotinamide adenine dinucleotide (NAD⁺) levels in the human brain in vivo by means of downfield proton MRS (DF ¹H MRS).

Methods

DF ¹H MRS was performed on 10 healthy volunteers in a 7.0 T MRI scanner with spectrally selective excitation and spatially selective localization to determine cerebral NAD⁺ levels on two back-to-back days: once after an overnight fast (baseline) and once 4 h after oral ingestion of nicotinamide riboside (900 mg). Additionally, two more baseline scans were performed following the same paradigm to assess test-retest reliability of the NAD⁺ levels in the absence of NR.

R

SUBMITTER: Nanga RPR 

PROVIDER: S-EPMC11436296 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature