The m⁶A methyltransferase METTL14 promotes cell proliferation via SETBP1-mediated activation of PI3K-AKT signaling pathway in myelodysplastic neoplasms.

ABSTRACT: N6-methyladenosine (m⁶A) is the most prevalent epitranscriptomic modification in mammalian mRNA. Recent studies have revealed m⁶A is involved in the pathogenesis of various malignant tumors including hematologic neoplasms. Nevertheless, the specific roles of m⁶A modification and m⁶A regulators in myelodysplastic neoplasms (MDS) remain poorly understood. Herein, we demonstrated that m⁶A level and the expression of m⁶A methyltransferase METTL14 were elevated in MDS patients with bone marrow blasts ≥5%. Additionally, m⁶A level and METTL14 expression were upregulated as the disease risk increased and significantly associated with adverse clinical outcomes. Knockdown of METTL14 inhibited cell proliferation and colony f

SUBMITTER: Jiang L 

PROVIDER: S-EPMC11436359 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature