Identification of leukemia stem cell subsets with distinct transcriptional, epigenetic and functional properties.

ABSTRACT: The leukemia stem cell (LSC) compartment is a complex reservoir fueling disease progression in acute myeloid leukemia (AML). The existence of heterogeneity within this compartment is well documented but prior studies have focused on genetic heterogeneity without being able to address functional heterogeneity. Understanding this heterogeneity is critical for the informed design of therapies targeting LSC, but has been hampered by LSC scarcity and the lack of reliable cell surface markers for viable LSC isolation. To overcome these challenges, we turned to the patient-derived OCI-AML22 cell model. This model includes functionally, transcriptionally and epigenetically characterized LSC broadly representative of LSC found in primary AML samples. Focusing on the pool of LSC, we used an integrat

SUBMITTER: Boutzen H 

PROVIDER: S-EPMC11436360 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature