Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption.

ABSTRACT: Human immunodeficiency virus (HIV) persistence during antiretroviral therapy (ART) is associated with heightened plasma interleukin-10 (IL-10) levels and PD-1 expression. We hypothesized that IL-10 and PD-1 blockade would lead to control of viral rebound following analytical treatment interruption (ATI). Twenty-eight ART-treated, simian immunodeficiency virus (SIV)mac₂₃₉-infected rhesus macaques (RMs) were treated with anti-IL-10, anti-IL-10 plus anti-PD-1 (combo) or vehicle. ART was interrupted 12 weeks after introduction of immunotherapy. Durable control of viral rebound was observed in nine out of ten combo-treated RMs for >24 weeks post-ATI. Induction of inflammatory cytokines, proliferation of effector CD8⁺ T cells in lymph nodes and reduced expression of BCL-2 i

SUBMITTER: Pereira Ribeiro S 

PROVIDER: S-EPMC11436369 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature