Development of ⁵²Mn Labeled Trastuzumab for Extended Time Point PET Imaging of HER2.

ABSTRACT:

Purpose

Due to their long circulation time in the blood, monoclonal antibodies (mAbs) such as trastuzumab, are usually radiolabeled with long-lived positron emitters for the development of agents for Positron Emission Tomography (PET) imaging. Manganese-52 (⁵²Mn, t_1/2 = 5.6 d, β⁺  = 29.6%, E(β_ave) = 242 keV) is suitable for imaging at longer time points providing a complementary technique to Zirconium-89 (⁸⁹Zr, t_1/2 = 3.3 d, β⁺  = 22.7%, E(β_ave) = 396 keV)) because of its long half-life and low positron energy. To exploit these properties, we aimed to investigate suitable bifunctional chelators that could be readily conjugated to antibodies and labeled with ⁵²Mn under mild conditions

SUBMITTER: Omweri JM 

PROVIDER: S-EPMC11436409 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature