Identification of Genogroup I and Genogroup II broadly reactive epitopes on the norovirus capsid.

ABSTRACT: Norwalk virus, a member of the family Caliciviridae, is an important cause of acute epidemic nonbacterial gastroenteritis. Norwalk and related viruses are classified in a separate genus of Caliciviridae called Norovirus, which is comprised of at least three genogroups based on sequence differences. Many of the currently available immunologic reagents used to study these viruses are type specific, which limits the identification of antigenically distinct viruses in detection assays. Identification of type-specific and cross-reactive epitopes is essential for designing broadly cross-reactive diagnostic assays and dissecting the immune response to calicivirus infection. To address this, we have mapped the epitopes on the norovirus capsid protein for both a genogroup I-cross-reactive monoclona

SUBMITTER: Parker TD 

PROVIDER: S-EPMC1143648 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature