Identification of GPNMB in endometrial cancer based on pan-cancer analysis and in vitro validation.

ABSTRACT:

Background

GPNMB is a type I transmembrane protein, and emerging evidence supports the relationship between GPNMB and cancers.

Objective

Through a comprehensive pan-cancer analysis, we examined the expression levels, prognostic significance, and mutation profiles of GPNMB in different cancer types. Subsequently, utilizing in vitro experiments, we elucidated the impact of GPNMB in endometrial cancer (EC).

Methods

TIMER2, GEPIA2, UALCAN and cBioPortal were used to analyze the expression pattern, prognostic values, and mutation status of GPNMB. HEC-1B and Ishikawa cells were used to conduct in vitro analyses of GPNMB overexpression. GeneMANIA and TIMER2 were used to evaluate the potential functions and correlations between GPNMB expression and tumor-infiltrating immune c

SUBMITTER: Tuo X 

PROVIDER: S-EPMC11436576 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature