Actin like 6A is a prognostic biomarker and associated with immune cell infiltration in cancers.

ABSTRACT:

Purpose

To investigate the role of Actin like 6 A (ACTL6A) in cancer and explore the potential mechanism of its function.

Methods

Differential expression of ACTL6A was analyzed using Oncomine and TIMER database. Then, we downloaded data sets from TCGA database. The correlation between ACTL6A expression and survival in pan-cancer were analyzed by "survival", "survminer" R package and PrognoScan database. STRING (v 11.0) and stringAPP for Cytoscape v3.7.2 were used to predict ACTL6A associated genes. Copy number and methylation alterations of ACTL6A were analyzed using cBioPortal and GSCALite. Transcription factors were downloaded from The Human Transcription Factors Database and analyzed using "limma" R package, JASPAR and PROMO database. Correlations analysis between ACTL6A

SUBMITTER: He Y 

PROVIDER: S-EPMC11436596 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature