Microenvironment-responsive, multimodulated herbal polysaccharide hydrogel for diabetic foot ulcer healing.

ABSTRACT: Diabetic ulcers (DUs) usually suffer from severe infections, persistent inflammation, and excessive oxidative stress during the healing process, which led to the microenvironmental alternation and severely impede DU healing, resulting in a delayed wound healing. Therefore, it is particularly important to develop a medical dressing that can address these problems simultaneously. To this end, self-healing composite hydrogels were prepared in this study utilizing Bletilla striata polysaccharide (BSP) and Berberine (BER) with borax via borate ester bond. The chemical and mechanical properties of the BSP/BER hydrogels were characterized, and their wound healing performance was investigated in vivo and in vitro. The results showed that the BSP/BER hydrogel significantly accelerated wound healing

SUBMITTER: Chen X 

PROVIDER: S-EPMC11436737 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature