Sprayable anti-adhesive hydrogel for peritoneal macrophage scavenging in post-surgical applications.

ABSTRACT: Post-surgical adhesions frequently occur after intra-abdominal surgery, leading to severe complications. Despite the development of various types of adhesion barriers to address post-surgical adhesions, several limitations persist, including off-target localization, handling difficulties, and potential immunogenicity. Here, we report a spray-type adhesion barrier for broad, fast application, forming two sequential networks. The first network is formed by a polyelectrolyte complex of sulfated hyaluronic acid and chitosan, while the second network is established through pluronic® F127 thermogelation. This sprayable barrier served as both a physical protector for the damaged peritoneum and an immunomodulator for peritoneal macrophages, as evidenced its effectiveness in a rat ischemic button m

SUBMITTER: Song W 

PROVIDER: S-EPMC11436759 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature