Delineation of global, absolutely essential and conditionally essential pangenomes of Porphyromonas gingivalis.

ABSTRACT: Porphyromonas gingivalis is a Gram-negative, anaerobic oral pathobiont, an etiological agent of periodontitis and the most commonly studied periodontal bacterium. Multiple low passage clinical isolates were sequenced, and their genomes compared to several laboratory strains. Phylogenetic distances were mapped, a gene absence-presence matrix generated, and core (present in all genomes) and accessory (absent in one or more genomes) genes delineated. Subsequently, a second pangenome delineating the prevalence of inherently essential genes was generated. The prevalence of genes conditionally essential for surviving tobacco exposure, abscess formation and epithelial invasion was also determined, in addition to genes encoding key proteolytic enzymes containing putative signal peptides. While the

SUBMITTER: Stocke K 

PROVIDER: S-EPMC11436796 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature