SARS-CoV-2 spike-specific nasal-resident CD49a⁺CD8⁺ memory T cells exert immediate effector functions with enhanced IFN-γ production.

ABSTRACT: Virus-specific nasal resident T cells are important for protection against subsequent infection with a similar virus. Here we examine the phenotypes and functions of SARS-CoV-2-specific T cells in the nasal mucosa of vaccinated individuals with breakthrough infection (BTI) or without infection. Nasal tissues are obtained from participants during sinus surgery. Analysis of activation-induced markers implicates that a considerable proportion of spike (S)-reactive nasal CD8⁺ T cells express CD103, a tissue-resident marker. MHC-I multimer staining is performed to analyze the ex vivo phenotype and function of SARS-CoV-2 S-specific CD8⁺ T cells. We detect multimer⁺CD8⁺ T cells with tissue-resident phenotypes in nasal tissue samples from vaccinees witho

SUBMITTER: Rha MS 

PROVIDER: S-EPMC11436836 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature