SO₂F₂ mediated click chemistry enables modular disulfide formation in diverse reaction media.

ABSTRACT: The dynamic disulfide linkage plays a vital role in various biological processes as well as drugs and biomaterials. The conversion of thiols to their corresponding disulfides is a hallmark of sulfur chemistry, but notoriously difficult to control. Achieving optimal reactivity and selectivity continues to pose significant challenges. Here, we describe a click chemistry for disulfide formation from thiols in both batch and flow-mode using SO₂F₂, which display exceptional selectivity toward disulfide formation through an effective nucleophilic substitution cascade. This reaction's unique characteristics satisfy the stringent click-criteria with its high thermodynamic driving force, straightforward conditions, wide scope, quantitative yields, exceptional chemoselectivity,

SUBMITTER: Li H 

PROVIDER: S-EPMC11436863 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature