Causal relationships between immunophenotypes, plasma metabolites, and temporomandibular disorders based on Mendelian randomization.

ABSTRACT: While numerous studies have underscored the implication of immune cells and metabolites in temporomandibular disorders (TMD), conclusive evidence for causality remains elusive. Consequently, our aim is to explore the causal connections between immunophenotypes and plasma metabolites in relation to TMD employing a bidirectional Mendelian randomization (MR) approach. Summary statistics data on 731 immunophenotypes (n = 3757) and 1091 plasma metabolites (n = 8299) were obtained from comprehensive genome-wide association studies (GWAS), while TMD data (5668 cases and 205,355 controls) were acquired from the FinnGen Consortium. Bidirectional MR analyses and a two-step MR approach assessed causal relationships and potential intermediaries. Various corrections and sensitivity analyses were utiliz

SUBMITTER: Qiu D 

PROVIDER: S-EPMC11436868 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature