Associations of traditional healthy lifestyle and sleep quality with metabolic dysfunction-associated fatty liver disease: two population-based studies.

ABSTRACT:

Aims

To examine whether an extended lifestyle metrics incorporating sleep quality improves risk stratification for metabolic dysfunction-associated fatty liver disease (MAFLD), at-risk metabolic dysfunction-associated steatohepatitis (MASH) and significant fibrosis.

Methods

A total of 5011 participants with abdominal ultrasound from Imaging sub-cohort of South China Cohort (ISSCC) and 3672 participants underwent vibration controlled transient elastography from US National Health and Nutrition Examination Survey (US NHANES) were included. Liver Essential 5 was constructed by incorporating sleep quality into traditional healthy lifestyles (HLS).

Results

A total of 4.66-17.72% of the association between traditional HLS and MAFLD was mediated by sleep quality regardless o

SUBMITTER: Yang J 

PROVIDER: S-EPMC11436947 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature