Telomere-to-telomere assemblies of cattle and sheep Y-chromosomes uncover divergent structure and gene content.

ABSTRACT: Reference genomes of cattle and sheep have lacked contiguous assemblies of the sex-determining Y chromosome. Here, we assemble complete and gapless telomere to telomere (T2T) Y chromosomes for these species. We find that the pseudo-autosomal regions are similar in length, but the total chromosome size is substantially different, with the cattle Y more than twice the length of the sheep Y. The length disparity is accounted for by expanded ampliconic region in cattle. The genic amplification in cattle contrasts with pseudogenization in sheep suggesting opposite evolutionary mechanisms since their divergence 19MYA. The centromeres also differ dramatically despite the close relationship between these species at the overall genome sequence level. These Y chromosomes have been added to the curre

SUBMITTER: Olagunju TA 

PROVIDER: S-EPMC11436988 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature