Activation of NPY2R-expressing amygdala neurons inhibits itch behavior in mice without lateralization.

ABSTRACT: The central amygdala (CeA) is a crucial hub in the processing of affective itch, containing a diverse array of neuronal populations. Among these components, Neuropeptide Y (NPY) and its receptors, such as NPY2R, affect various physiological and psychological processes. Despite this broad impact, the precise role of NPY2R⁺ CeA neurons in itch modulation remains unknown, particularly concerning any potential lateralization effects. To address this, we employed optogenetics to selectively stimulate NPY2R⁺ CeA neurons in mice, investigating their impact on itch modulation. Optogenetic activation of NPY2R⁺ CeA neurons reduced scratching behavior elicited by pruritogens without exhibiting any lateralization effects. Electrophysiological recordings confirmed incre

SUBMITTER: Pavlenko D 

PROVIDER: S-EPMC11437048 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature