Sex differences in brain functional specialization and interhemispheric cooperation among children with autism spectrum disorders.

ABSTRACT: The prevalence of autism spectrum disorders (ASDs) differs substantially between males and females, suggesting that sex-related neurodevelopmental factors are central to ASD pathogenesis. Numerous studies have suggested that abnormal brain specialization patterns and poor regional cooperation contribute to ASD pathogenesis, but relatively little is known about the related sex differences. Therefore, this study examined sex differences in brain functional specialization and cooperation among children with ASD. The autonomy index (AI) and connectivity between functionally homotopic voxels (CFH) derived from resting-state functional magnetic resonance imaging (rs-fMRI) were compared between 58 male and 13 female children with ASD. In addition, correlations were examined between regional CFH v

SUBMITTER: Li H 

PROVIDER: S-EPMC11437118 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature