Magnetic augmentation through multi-gradient coupling enables direct and programmable profiling of circulating biomarkers.

ABSTRACT: Conventional magnetic biosensing technologies have reduced analytical capacity for magnetic field dimensionality and require extensive sample processing. To address these challenges, we spatially engineer 3D magnetic response gradients for direct and programmable molecular detection in native biofluids. Named magnetic augmentation through triple-gradient coupling for high-performance detection (MATCH), the technology comprises gradient-distributed magnetic nanoparticles encapsulated within responsive hydrogel pillars and suspended above a magnetic sensor array. This configuration enables multi-gradient matching to achieve optimal magnetic activation, response and transduction, respectively. Through focused activation by target biomarkers, the platform preferentially releases sensor-proxima

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11437193 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature