Small RNAs and tooth development: The role of microRNAs in tooth agenesis and impaction.

ABSTRACT:

Background/purpose

Tooth development, or odontogenesis, is a complex process in which several molecular pathways play a key role. Recently, microRNAs, a class of approximately 20-nucleotide small RNA molecules that regulate gene expression, have been implicated in the odontogenesis process. This study aimed to assess the role of miRNAs in odontogenesis anomalies, specifically agenesis and impaction.

Materials and methods

We analyzed a manually curated list of 82 miRNAs associated with human odontogenesis, sourced from literature data. Employing two different approaches to validate findings, we conducted functional enrichment analysis to evaluate the cell pathways, diseases, and phenotypes enriched for those miRNAs.

Results

Our findings indicate that the analyzed miRNA

SUBMITTER: Giovannetti A 

PROVIDER: S-EPMC11437305 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature