ScDAPP: a comprehensive single-cell transcriptomics analysis pipeline optimized for cross-group comparison.

ABSTRACT: Single-cell transcriptomics profiling has increasingly been used to evaluate cross-group (or condition) differences in cell population and cell-type gene expression. This often leads to large datasets with complex experimental designs that need advanced comparative analysis. Concurrently, bioinformatics software and analytic approaches also become more diverse and constantly undergo improvement. Thus, there is an increased need for automated and standardized data processing and analysis pipelines, which should be efficient and flexible too. To address these, we develop the single-cell Differential Analysis and Processing Pipeline (scDAPP), a R-based workflow for comparative analysis of single cell (or nucleus) transcriptomic data between two or mor

SUBMITTER: Ferrena A 

PROVIDER: S-EPMC11437360 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature