Buprenorphine-Precipitated Withdrawal Among Hospitalized Patients Using Fentanyl.

ABSTRACT:

Importance

Buprenorphine treatment of opioid use disorder (OUD) is safe and effective, but opioid withdrawal during treatment initiation is associated with poor retention in care. As fentanyl has replaced heroin in the drug supply, case reports and surveys have indicated increased concern for buprenorphine-precipitated withdrawal (PW); however, some observational studies have found a low incidence of PW.

Objective

To estimate buprenorphine PW incidence and assess factors associated with PW among emergency department (ED) or hospitalized patients.

Design, setting, and participants

This retrospective cohort study at 3 academic hospitals in Philadelphia, Pennsylvania, included adults with OUD who underwent traditional or high-dose buprenorphine initiation between January

SUBMITTER: Thakrar AP 

PROVIDER: S-EPMC11437388 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature