Increased Virulence of <i>Culicoides</i> Midge Cell-Derived Bluetongue Virus in IFNAR Mice.

ABSTRACT: Bluetongue (BT) is a Culicoides midge-borne hemorrhagic disease affecting cervids and ruminant livestock species, resulting in significant economic losses from animal production and trade restrictions. Experimental animal infections using the α/β interferon receptor knockout IFNAR mouse model and susceptible target species are critical for understanding viral pathogenesis, virulence, and evaluating vaccines. However, conducting experimental vector-borne transmission studies with the vector itself are logistically difficult and experimentally problematic. Therefore, experimental infections are induced by hypodermic injection with virus typically derived from baby hamster kidney (BHK) cells. Unfortunately, for many U.S. BTV serotypes, it is difficult to replicate the severity of the d

SUBMITTER: Drolet BS 

PROVIDER: S-EPMC11437402 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature