Immunogenicity of an Inactivated COVID-19 Vaccine in People Living with HIV in Guangxi, China: A Prospective Cohort Study.

ABSTRACT: The inactivated COVID-19 vaccine has demonstrated high efficacy in the general population through extensive clinical and real-world studies. However, its effectiveness in immunocompromised individuals, particularly those living with HIV (PLWH), remains limited. In this study, 20 PLWH and 15 HIV-seronegative individuals were recruited to evaluate the immunogenicity of an inactivated COVID-19 vaccine in PLWH through a prospective cohort study. The median age of the 20 PLWH and 15 HIV-seronegative individuals was 42 years and 31 years, respectively. Of the PLWH, nine had been on ART for over five years. The median anti-SARS-CoV-2 S-RBD IgG antibody level on d₂₂₄ was higher than that on d₄₂ (8188.7 ng/mL vs. 3200.9 ng/mL, P < 0.05). Following COVID-19 infection, th

SUBMITTER: Wu Y 

PROVIDER: S-EPMC11437430 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature