Patterns of Transmitted Drug Resistance Mutations and HIV-1 Subtype Dynamics in ART-Naive Individuals in Veneto, Italy, from 2017 to 2024.

ABSTRACT: This study investigates the prevalence and patterns of transmitted drug resistance mutations (TDRMs) and HIV-1 subtypes among antiretroviral therapy (ART) naïve individuals in Veneto, Italy, from 2017 to 2024. This research aims to understand the dynamic landscape of TDRMs and HIV-1 genetic diversity to inform treatment strategies effectively. We included all adult ART-naïve people with HIV (PWH) from seven infectious disease units in Veneto, Italy. We collected the genotypic resistance testing conducted to predict drug susceptibility and subtype distribution using the Stanford HIVdb algorithm. We included 762 PWH, showing a slight but statistically significant decline in the B subtype among Italian PWH (p = 0.045) and an increase in non-B subtypes among foreigners, though it was no

SUBMITTER: Geremia N 

PROVIDER: S-EPMC11437434 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature