HSV-2 Manipulates Autophagy through Interferon Pathway: A Strategy for Viral Survival.

ABSTRACT: Autophagy, an evolutionarily conserved cellular process, influences the regulation of viral infections. While the existing understanding indicates that Herpes Simplex Virus type 2 (HSV-2) maintains a basal level of autophagy to support its viral yield, the precise pathways governing the induction of autophagy during HSV-2 infection remain unknown. Therefore, this study aims to explore the role of type I interferons (IFN-I) in modulating autophagy during HSV-2 infection and to decode the associated signaling pathways. Our findings revealed an interplay wherein IFN-I regulates the autophagic response during HSV-2 infection. Additionally, we investigated the cellular pathways modulated during this complex process. Exploring the intricate network of signaling events involved in autophagy induc

SUBMITTER: Dass D 

PROVIDER: S-EPMC11437441 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature