Differing Transcriptomic Responses in High Titer versus Low Titer <i>Aedes aegypti</i> Mosquitoes after Oral Infection with Sindbis Virus.

ABSTRACT: Oral infection of mosquitoes by arboviruses often results in a large degree of variation in the amount of infectious virus between individual mosquitoes, even when the mosquitoes are from inbred laboratory strains. This variability in arbovirus load has been shown to affect virus transmissibility. Previously, our group described population genetic and specific infectivity differences between the virus populations found in high and low titer Aedes aegypti mosquitoes that had been orally infected with Sindbis virus (SINV). In this study, we sought to investigate whether there were also differences in transcriptomic response between these high and low titer mosquitoes. Results from the transcriptomic data analysis showed that more genes involved in antiviral activity, endopeptidase act

SUBMITTER: Hodoameda P 

PROVIDER: S-EPMC11437473 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature