Secreted protein TNA: a promising biomarker for understanding the adipose-bone axis and its impact on bone metabolism.

ABSTRACT:

Background

Osteoporosis (OP) is a systemic bone disease characterized by reduced bone mass and deterioration of bone microstructure, leading to increased bone fragility. Platelets can take up and release cytokines, and a high platelet count has been associated with low bone density. Obesity is strongly associated with OP, and adipose tissue can influence platelet function by secreting adipokines. However, the biological relationship between these factors remains unclear.

Methods

We conducted differential analysis to identify OP platelet-related plasma proteins. And, making comprehensive analysis, including functional enrichment, protein-protein interaction network analysis, and Friends analysis. The key protein, Tetranectin (TNA/CLEC3B), was identified through screening. The

SUBMITTER: Wu S 

PROVIDER: S-EPMC11437659 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature