Clinicopathological and prognostic significance of stromal cell derived factor 2 in the patients with gastric cancer.

ABSTRACT:

Background

The stromal cell derived factor 2 (SDF2) relates closely to the occurrence and development of several kind of cancers. There are few studies to investigate the clinicopathological and prognostic significance of SDF2 in gastric cancer (GC) patients.

Methods

We detected SDF2 expression in GC and normal gastric tissues using bioinformatics, western blot and immunohistochemistry. Furthermore, we tested the relationship between SDF2 expression and clinicopathological characteristics and prognosis of GC patients.

Results

Bioinformatics, western blot and immunohistochemistry results showed that SDF2 expression in GC tissue was higher than that in normal gastric tissue (P < 0.01). SDF2 expression was associated with Borrmann classification III-IV (χ² = 6

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11437680 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature