Prognostic value and molecular mechanisms of OAS1 in lung adenocarcinoma.

ABSTRACT:

Background

The expression of 2'-5'-oligoadenylate synthetase 1 (OAS1) in lung cancer has been validated in numerous studies. However, the prognostic value of OAS1 expression in lung adenocarcinoma (LUAD) still remains unclear. This study aimed to reveal the prognostic value and associated molecular mechanisms of OAS1 expression in LUAD.

Methods

Gene expression data of LUAD were extracted from online databases. Gene and protein expression levels of OAS1 in LUAD and normal samples were revealed, followed by prognostic analysis of OAS1. Next, we conducted a thorough bioinformatics analysis to examine the enrichment of key functional and biological signaling pathways and their correlation with the abundance of immune cells. The independent prognoses, drug responses, and PPI netw

SUBMITTER: Wang L 

PROVIDER: S-EPMC11437775 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature