Unraveling the role of lactate-related genes in myocardial infarction.

ABSTRACT:

Background

Lactate is a crucial intermediary, facilitating communication between myocardial energy metabolism and microenvironmental regulation. The present study aimed to investigate the relationship between lactate-related genes (LRGs) and myocardial infarction (MI).

Methods

A total of 23 LRGs exhibited differential expression between individuals with MI and healthy controls. Lasso regression analysis and validation with the GSE61144 dataset identified three hub genes: COX20, AGK, and PDHX. Single-gene GSEA of these genes revealed strong enrichment in pathways related to amino acid metabolism, cell cycle, and immune functions. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was utilized to validate the expression levels of the hub genes.

Results</

SUBMITTER: Xu R 

PROVIDER: S-EPMC11437837 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature