Shenqi Sanjie Granules induce Hmox1-mediated ferroptosis to inhibit colorectal cancer.

ABSTRACT:

Background

Because adverse reactions or drug resistance are often found after current chemotherapies for metastatic colorectal cancer (mCRC), new treatments are still in demand. Shenqi Sanjie Granules (SSG), an antitumor compound preparation of traditional Chinese medicine, has been recognized for its ability in clinical practice of oncotherapy. Nevertheless, the precise effects of SSG in colorectal cancer (CRC) and underlying mechanisms through which SSG inhibits CRC remain uncertain. The current study aimed to evaluate the anti-CRC activity of the Chinese herbal compound preparation SSG and investigate the underlying mechanisms of action.

Materials and methods

Initially, nine distinct cancer cell lines, including five CRC cell lines, one breast cancer cell line, two lung a

SUBMITTER: Chen M 

PROVIDER: S-EPMC11437928 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature