Association between perioperative hemoglobin decrease and outcomes of transfusion in patients undergoing on-pump cardiac surgery: An observational study from two Chinese heart centers.

ABSTRACT:

Background

It is unclear how perioperative hemoglobin decrease (ΔHb) influences the balance between risks and benefits of red blood cell transfusion after cardiac surgery.

Methods

We retrospectively analyzed data on 8186 adults who underwent valve surgery and/or coronary artery bypass grafting under cardiopulmonary bypass at two large cardiology centers. We explored the potential association of ΔHb, defined relative to the preoperative level and postoperative nadir, with a composite outcome of in-hospital mortality, myocardial infarction, stroke, and acute kidney injury using multivariable logistic regression, restricted cubic spline, and piecewise-linear models.

Results

Among 6316 patients without preoperative anemia, ΔHb ≥ 50 % was associated with an elevated risk o

SUBMITTER: He J 

PROVIDER: S-EPMC11437932 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature