A urine-based liquid biopsy for detection of upper tract urothelial carcinoma: a self-matched study.

ABSTRACT:

Background

To establish the pathological diagnosis of UTUC before treatment is profitable. At present, the conventional pathological diagnostic methods have certain problems. Besides, the urine-based DNA methylation test have been already utilized to detect bladder cancer.

Objective

To evaluate the sensitivity and specificity of DNA methylation plus 17 genes mutation test and compare the combined test with cytology.

Materials and methods

We included 45 patients from April 2019 to May 2022, all of whom underwent radical nephroureterectomy (RNU), nephrectomy, diagnostic ureteroscopy or tissue biopsy. Before surgery, the urine samples were collected for DNA methylation plus 17 genes mutation test and cytology. The test performance was calculated, and comparative ROC curv

SUBMITTER: Wei W 

PROVIDER: S-EPMC11438001 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature