Clinical significance of the genetically variable landscape of the gut microbiome in patients with gestational diabetes mellitus patients.

ABSTRACT:

Background

The composition of the gut microbiome has been recorted to be strongly associated with gestational diabetes mellitus (GDM), but mutational characterization of the microbiome in patients with GDM has been overlooked. Here, we revealed the genetic variation landscape of the gut microbiome and assessed its clinical significance in a cohort of patients with GDM.

Methods

We employed a macrogenomic dataset made up of a discovery cohort of 54 cases and a validation cohort of 220 cases to screen for high-abundance microbial flora and identified single nucleotide variants (SNVs) and insertions/deletions (indels). Subsequently, we analyzed the mutation spectra of genomes of the intestinal flora by using the previously identified SNVs and identified mutation signatures. Addi

SUBMITTER: Zhang K 

PROVIDER: S-EPMC11438002 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature