Evaluation of the immunization efficacy and adverse reactions of hepatitis B vaccination in children with thalassemia minor.

ABSTRACT:

Objective

To assess the immunization efficacy and incidence of adverse reactions after hepatitis B vaccination in children with thalassemia based on data from real-world studies.

Methods

A total of 625 children were recruited into this cross-sectional study. Subgroup analyses of different thalassemia types were performed using binary logistic regression, the factors affecting HBsAb levels were identified using multiple linear regression, and the dose-response relationship between the duration of immunization and seroconversion was explored using the restricted cubic spline (RCS) model to further assess the protective duration of the hepatitis B vaccine.

Results

HBsAb positivity in enrolled children was 87.3% in the thalassemia group and 81.4% in the control group. Mul

SUBMITTER: Han X 

PROVIDER: S-EPMC11438186 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature