Age- and ethnic-driven molecular and clinical disparity of East Asian breast cancers.

ABSTRACT:

Background

Breast cancer (BC) is a complex disease with profound genomic aberrations. However, the underlying molecular disparity influenced by age and ethnicity remains elusive.

Methods

In this study, we aimed to investigate the molecular properties of 843 primary and metastatic BC patients enrolled in the K-MASTER program. By categorizing patients into two distinct age subgroups, we explored their unique molecular properties. Additionally, we leveraged large-scale genomic data from the TCGA and MSK-IMPACT studies to examine the ethnic-driven molecular and clinical disparities.

Results

We observed a high prevalence of PI3KCA mutations in K-MASTER HER2 + tumors, particularly in older patients. Moreover, we identified increased mutation rates in DNA damage response mol

SUBMITTER: Lee JY 

PROVIDER: S-EPMC11438198 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature