Whole genome sequencing and characterization of Corynebacterium isolated from the healthy and dry eye ocular surface.

ABSTRACT:

Background

The purpose of this study was to characterize Corynebacterium isolated from the ocular surface of dry eye disease patients and healthy controls. We aimed to investigate the pathogenic potential of these isolates in relation to ocular surface health. To this end, we performed whole genome sequencing in combination with biochemical, enzymatic, and antibiotic susceptibility tests. In addition, we employed deferred growth inhibition assays to examine how Corynebacterium isolates may impact the growth of potentially competing microorganisms including the ocular pathogens Pseudomonas aeruginosa and Staphylococcus aureus, as well as other Corynebacterium present on the eye.

Results

The 23 isolates were found to belong to 8 different species of Corynebacterium with genome

SUBMITTER: Naqvi M 

PROVIDER: S-EPMC11438203 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature